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Monday, 23 October 2017

Keep your own medical records


NHS boss reveals loss of further 162 000 pieces of medical correspondence


BMJ 2017; 359 doi: https://doi.org/10.1136/bmj.j4822 (Published 17 October 2017) Cite this as: BMJ 2017;359:j4822

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1.                         Gareth Iacobucci

1.The BMJ

The loss of more than 700 000 items of NHS clinical correspondence, reported earlier this year, has been compounded after officials admitted that a further 162 000 patient files went missing over five years.
The scandal first emerged in March 2016, when it was discovered that hundreds of thousands of files, including test results and diagnoses, were misplaced between 2011 and 2016 before they were delivered to hospitals and GPs in England by NHS Shared Business Services, an agency co-owned by the Department of Health and the IT company Sopra Steria. In June this year a National Audit Office inquiry identified around 1700 cases where patients could have been harmed as a result

Wednesday, 27 September 2017

APRIL charity web site now back on line at www.april.org.uk


APRIL - Adverse Psychiatric Reactions Information Link


Our web site is back on line now click here to access  www.april.org.uk for information about many medicines linked to neuro-psychiatric adverse reactions, support groups, articles, videos of doctor's advice, personal experiences and much more.

If you previously found the url www.april.org.uk redirected you to this blog site, that was just during the time the new web site was being created. You may need to 'clear Internet History' to access the new web site.

Please continue reviewing this APRIL charity blog from time to time for updates on latest research or news by inserting https://aprilcharity.blogspot.co.uk into the url box.

Our new web site at www.april.org.uk will continue being updated with content, so please refer back on a regular basis for added content. 

Adverse Drug Reactions (ADRs) and withdrawal effects changing mood and behaviour, need to be studied and understood.

We hope the information will be valuable for doctors and prescribers and those of us who rely on them to stay well.

Informed choice is the key, as awareness saves lives.

 How many more stories like the Sodium Valproate tragedy, of harm from medicines, will we have to hear before the medical profession have the kind of education we believe they are deprived of? Not only were women not informed, some prescribers played down the risks. 

We all have a right to know about even so called rare adverse drug reactions (ADRs) . Who knows how rare, when less than 10% of serious ADRs are reported? (MHRA statistic)

The warnings are often overlooked by prescribers and informed choice denied to patients. The voices of those who suffer, or are bereaved, often fall on deaf ears.

       APRIL,  the charity that believes Awareness Saves Lives

posted by Millie Kieve
www.april.org.ukwww.april.org.uk

Wednesday, 31 May 2017

Please donate to APRIL the charity acting on behalf of victims of adverse drug reactions



Please donate to help APRIL as we rely on supporters, friends and family
to continue our efforts to improve patient safety.   http://www.charitychoice.co.uk/april

Monday, 8 May 2017

Another tragic suicide linked to acne drug Roaccutane

http://www.eadt.co.uk/news/our-happy-go-lucky-luke-changed-after-taking-acne-drug-colchester-family-say-after-son-s-suicide-1-5005927

The tragic suicide in May 2017 of 21 year old Luke Reeves is so sad and one wonders if the consultant who prescribed the drug Roaccutane (isotretinoin) was taken in by the manufacturer's claim that suicides linked to the drug are 'rare'. The need to monitor patients on some drugs know to have psychiatric adverse effects is often not followed.

isotretinoin called Accutane in the USA and Roaccutane in the UK is a drug derived from Vitamin A with known serious adverse side effects, works for some people to reduce their acne - but for others it can lead to tragic ill health, long term depression and in some cases suicide.

I just sent the following information to a journalist:

My main comment is that parents should look a the pharmaceutical company data sheet

 which states under the heading
 4.4 Special warnings and precautions for use:

Psychiatric disorders
Depression, depression aggravated, anxiety, aggressive tendencies, mood alterations, psychotic symptoms, and very rarely, suicidal ideation, suicide attempts and suicide have been reported in patients treated with isotretinoin (see section 4.8). Particular care needs to be taken in patients with a history of depression and all patients should be monitored for signs of depression and referred for appropriate treatment if necessary. However, discontinuation of isotretinoin may be insufficient to alleviate symptoms and therefore further psychiatric or psychological evaluation may be necessary

And further, what they found in the original clinical trials is nothing to go by as the clinical trials can be rigged (talks on APRIL’ Vimeo site by Dr BenGoldacre https://vimeo.com/15986864
 
and Prof David Healy explain how this is done! Even if they reccon 1 in 10,000 dies by suicide how many millions are given the drug and how many hundred or thousands of families lose their lovely kids. – oh and the MHRA admit less than 10% of serious ADRs (Adverse drug reactions) are reported!

The data sheet also contains the following information for istotretinoin /Ro-Accutane under the heading:

4.8 Undesirable effects

Psychiatric disorders:
Rare (≥ 1/10 000,<1 o:p="">
Very Rare (≤ 1/10 000)
Depression, depression aggravated, aggressive tendencies, anxiety, mood alterations
Abnormal behaviour, psychotic disorder, suicidal ideation, suicide attempt, suicide
Nervous system disorders:
Common (≥1/100, <1 o:p="">

Very Rare (≤ 1/10 000)
Headache
Benign intracranial hypertension, convulsions, drowsiness, dizziness

Monday, 1 May 2017

Clinical Trial Study 329 Ghostwritten by GSK - reanalysis of review of Seroxat Paxil


Restoring Study 329 - The study that disproved anti-depressants’ efficacy

A major reanalysis of the infamous clinical trial, Study 329, has shown Paroxetine (also known as Paxil or Seroxat), one of the most commonly prescribed antidepressants, to be unsafe and no more effective than a placebo.

This new assessment directly contradicts the results of the clinical trial that claimed Seroxat to be “generally well tolerated and effective”, which was sponsored by and ghostwritten for GlaxoSmithKline, despite using the same original data.

The latest paper was published under the restoring invisible and abandoned trials (RIAT) initiative, in order to re-evaluate any conclusions drawn from evidence that had previously been hidden from public view.

Published in 2001, Study 329 generated a high level of controversy from patients and doctors after lawsuits were filed stating the side-effects were much more serious than those documented in the clinical trials.

Restoring Study 329, showed Paroxetine (Seroxat or Paxil) to have no significant reduction of depressive symptoms more than a placebo or previous anti-depressants, and gave users a higher chance of psychiatric side effects.

The original study came under intense scrutiny following revelations that it was ghost written by GSK authors and not those named on the study, and the primary data was not made publically available.

The findings of Study 329, originally published in 2001, was the first double blind patient study to report the efficacy of anti-depressants on adolescents.

It has allowed Seroxat to gain widespread approval by the healthcare industry, becoming the most widely prescribed anti-depressant in the US, with over 14 billion dolllars worth of sales between 1997 and 2004.

Following a decade of public and legal pressure, GSK finally released the original data to the public, making its reanalysis possible.

These devastating results overturning the original paper may come as no surprise to many who have already suffered loss and harm from the drug. In  2012 GSK were successfully sued $3 billion for fraudulently promoting Paroxetine to the public, and hiding key data in its study, such as reclassifying suicidal acts so that they would not count in the final analysis.

To this day however, GSK remain silent on the issue and continue to promote the drug to its customers, without any attempt to acknowledge the restoration of the study.

A personal note to our readers:

As we reveal these facts about Seroxat, we do not wish to condemn all use of anti-depressants nor encourage the immediate withdrawal from the medication.  It is important to obtain advice from responsible health professionals who can help to plan any reduction in drugs that may cause dependence. It is also important to inform those close to you when you plan to start, reduce or stop taking antidepressants and to obtain professional medical or support group assistance and advice. 

We wish to highlight the potential dangers and risks of Paroxetine and similar medication, and let readers understand that medical information to support the drug can be unreliable or biased.

Both starting and coming off anti-depressants is a serious undertaking and we strongly advise that users seek professional medical help as well as inform either close friends or family when doing so, as it can be a tough process which needs careful monitoring and support.

Dealing with life events can cause anxiety but may not be depression. We recommend considering talking therapy, possible CBT- cognitive behavioural therapy for those who have access to these services, as these have been shown to provide beneficial reductions of depression and anxiety with fewer and less serious side effects.

Specialised bereavement counselling is also of benefit as it is more difficult for some people to express grief when blocked by drug effects.

 

©JBforAPRIL

 

Further Reading

 

Article on Study 329


British Medical Journal Analysis of Study 329


David Healy’s website on the controversy of Study 329


Restored Study 329


Wednesday, 12 April 2017

well worth watching and hearing psychiatrist Dr Joanna Moncrieff speak at the end of the video - her comments about 'Disease Awareness' campaigns and the fact there is no scientific evidence for the promotion by the pharmaceutical industry in their campaigns of a 'chemical imbalance' as a cause of mental distress should he heard by all medical students. Together with reading her book 'The Myth of the Chemical Cure' - if on the medical curriculum we may in the future see a reduction in iatrogenic illness. That is the ill health actually caused by the treatment. The rise in iatrogenesis is a public health crisis which the Department of Health would be wise to take into account when looking at the cost of emergency admissions to hospital.

The increase in emergency admissions to A & E caused by adverse drug reactions (ADRs) was highlighted in the Imperial College review of 10 years of hospital statistics. The increase by 76.8% was the fastest increase of any cause of admission. The human and financial cost is massive.

Thursday, 11 August 2016

Our web site is being updated


Blog post - latest update 15 December 2016

You will have been re-directed to our blog while our web site is in the process of being upgraded and edited, for which we apologise.

Please read here :
our submission to the Parliamentary Health Select Committee Inquiry into Suicide Prevention

The final report by the committee totally ignored the medication links to suicides, stating the view of those who gave oral evidence was that treatment with drugs is better than no treatment. How sad they could not discuss the fact there are suicide warnings for many psychotropic and everyday medicines.

APRIL charity has had a web site for over 15 years - this is currently being upgraded.

By early 2017 we should have an improved site up and running - In the meantime please read articles on this blog and  view our videos from our groundbreaking conferences.

Leading experts in clinical pharmacology, genetics and medical education. speak and answer questions about adverse drug reactions (ADRs), and dependence issues.


Hear about the way clinical trials may be manipulated explained by Dr Ben Goldacre and Professor David Healy. The wonderful Professor Heather Ashton's wise words and many other experts in the field of medicine. A coroner's view and the stories of people, some bereaved, who kindly agreed to sharing their experiences with us.


https://vimeo.com/user1816628 


We also have a Youtube channel to which over 40,000 people have seen and some have commented. Well worth reading those comments to hear how people have suffered and how valuable our work of creating awareness is. Please find information about specific drugs on the pharma web site www.medicines.org.uk and review the data on the SPC (summary of product characteristics) for full information about some of the possible side effects.

Please follow us on Twitter @APRIL_charity 

Our submission to the Government Suicide Prevention Inquiry can be viewed on the Parliamentary web site: 
http://data.parliament.uk/writtenevidence/committeeevidence.svc/evidencedocument/health-committee/suicide-prevention/written/37700.pdf

 We take the opportunity to request if you may please consider a contribution to help us continue in our work.

Donations towards the upgrade of the web site will be appreciated - please read our Fundraising Appeal here:

Link to Charity Choice Fundraising site, click on 'Our Appeals : https://www.charitychoice.co.uk/april

Direct link to the Appeal:
https://www.charitychoice.co.uk/april/appeals/psychiatric-side-effects-major-resource-upgrade-of-web-site/626

Latest news on activities of APRIL


Please share the link for this remarkable new video documentary by Katinka Newman but can only be viewed on a computer - not on mobile devices unfortunately!
https://www.youtube.com/watch?v=eEeJtRB5hqg


Oxford University Press International Journal of Neuropsychopharmacology

A newly published paper = October 2016  referring to rigged clinical trials covering up suicides and other ADRs caused by antidepressants is also worth reviewing:

http://ijnp.oxfordjournals.org/content/early/2016/10/25/ijnp.pyw092


Please scroll down this blog for important information about antidepressants, Dianette, Non psychiatric drugs linked to suicidal behaviour and depression in a recent study by Professor Munir Pirmohamed and others.

Until the revised web site is available, it is still possible to research the information about medicines or other data on our web site archived by Wayback Machine - just go to the web site : http://web.archive.org/web/*/www.april.org.uk

waybackmachine.org is a great resource and they state for www.april.org.uk it has been
Saved 158 times between August 24, 2000 and April 26, 2016.

Antimalarial drug
31 August 2016 on BBC TV Victoria Derbyshire programme focus was partly on the #psychiatric adverse reactions to #Lariam #Mefloquine the drug recommended for prevention of #malaria


Follow her on twitter too: @VictoriaLive 

After hearing the evidence in the programme one may wonder why nothing was done to protect the public and our troops from the long term mental health issues triggered by this drug, there are suicides and homicides linked to the adverse effects too. 

The answer is the pharmaceutical company threatened that if any kind of campaigning were to continue in the UK the cost would be too great.

details are here:

APRIL has a dossier of testaments from the public about the dreadful effects of the drug. It may be of use for 'curing' malaria but as a preventative the harm seems to outweigh the benefit.
_____________________________________________________________

Apart from editing and revising the web site, Millie Kieve the founder of APRIL Tweets to doctors and others - Please follow us on Twitter @APRIL_charity

This week a good result was when Dr Mark Porter mention Millie Kieve had tweeted to ask why he did not promote patient reporting of ADRs:
http://www.bbc.co.uk/programmes/b07mxk4g  BBC broadcast 9th & 10th August 2016

After radio 4 programme 'Inside Health' prog last week (2nd & 3rd August), item on statins, when they discussed the conflicting evidence re benefits and harms. I tweeted direct to Dr Mark Porter how important to balance the misinformation and why did he not promote the Yellow Card reporting system for patients as doctors so seldom report ADRS. (more than one tweet of course as words so limited in tweets!) - I believe the incidents of memory loss, depression and muscle weakness caused by statins is under reported!



And Dr Porter quoted my tweet to instigate a discussion on Yellow Card reporting in this week's prog and even mentioned my name!

This is about 15 mins into the programme after the hip treatment discussion. 


I hope the MHRA will be pleased but still wonder why they don't do more to publicise the Yellow Card system. This lack of effort to promote the scheme to the public re-enforces the Health Committee Inquiry finding:
The MHRA have a conflict of interest in trying to manage safety of medicines while they are supported by and have to promote the pharmaceutical industry.